2-Fluorophenol → 4-tert-butyl-2-fluorophenol
反応式
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)([CH3:8])([CH3:7])[CH3:6].[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:17]>O>[C:5]([C:15]1[CH:14]=[CH:13][C:12]([OH:17])=[C:11]([F:10])[CH:16]=1)([CH3:8])([CH3:7])[CH3:6]参加物
5
実験手順
Aluminum chloride and tert-butyl chloride were added under ice-cooling to 2-fluorophenol and stirred at room temperature. By adding water to the reaction liquid, concentrating the organic layer under a reduced pressure and crystallizing from hexane, 4-tert-butyl-2-fluorophenol was obtained.
後処理
- customto the reaction liquid
- concentrationconcentrating the organic layer under a reduced pressure
- customcrystallizing from hexane
出典と根拠
- ORDレコード
- ord-5bd8c46fcc1a459bb54347dcb7faae36
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08106190B2
反応ノート
読み込み中…