N-bromobutanimide → 3-Bromomethyl-5-methyl-benzaldehyde
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[CH2:5][O:6]C(=O)C1C=CC=CC=1.C1C(=O)N([Br:26])C(=O)C1>C(Cl)(Cl)(Cl)Cl.[W]>[Br:26][CH2:1][C:2]1[CH:3]=[C:4]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[CH:5]=[O:6]参加物
5
実験手順
A mixture of benzoic acid 3,5-dimethyl-benzyl ester (24 g, 0.1M) and NBS (39.16 g, 0.22M) in carbon tetrachloride (200 ml) was refluxed for 3 hr. under a light of 500 W tungsten lamp. After cooling to room temperature, the mixture was filtered and the filtrate was evaporated in vacuo. The residue was dissolved in ether, washed with aqueous saturated sodium bicarbonate solution, dried with anhydrous magnesium sulfate, filtered, and evaporated in vacuo to give 21 g of crude 3-bromomethyl-5-methyl-benzaldehyde.
後処理
- temperaturewas refluxed for 3 hr
- filtrationthe mixture was filtered
- customthe filtrate was evaporated in vacuo
- dissolutionThe residue was dissolved in ether
- washwashed with aqueous saturated sodium bicarbonate solution
- dry with materialdried with anhydrous magnesium sulfate
- filtrationfiltered
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-4617f54282e44353853d4fc876310e6e
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08106064B2
反応ノート
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