Acetonitrile → N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-furansulfonamide

HRID 426445

反応式

HRID 426445 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([N:9]=[C:10]=[O:11])(=[O:8])=[O:7].[NH2:12][C:13]1[N:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([CH3:21])[N:14]=1.C(#N)C>C(Cl)Cl>[CH3:20][O:19][C:17]1[CH:16]=[C:15]([CH3:21])[N:14]=[C:13]([NH:12][C:10]([NH:9][S:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)(=[O:7])=[O:8])=[O:11])[N:18]=1

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 5872364-Methoxy-6-methylpyrimidin-2-amineHCID 233424782-Furansulfonyl isocyanate

生成物 1

HCID 20390812N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-furansulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2.10 g of 2-furansulfonyl isocyanate in 40 ml of methylene chloride was added 1.60 g 2-amino-4-methoxy-6-methylpyrimidine. The resulting mixture was stirred for 1 hour at room temperature, then refluxed for 15 minutes, and the solvent was removed under vacuum. The solid obtained was allowed to stand under ethyl ether containing a trace of acetonitrile for one day, and was then filtered and dried to give the desired product melting at 185°-188° (dec).

後処理

  1. temperaturerefluxed for 15 minutes
  2. customthe solvent was removed under vacuum
  3. customThe solid obtained
  4. customfor one day
  5. filtrationwas then filtered
  6. customdried

出典と根拠

ORDレコード
ord-e008343bb5c146f7a23cf3c4aa20f90c
出典データセット
uspto-grants-1979_10
特許番号
US04169719

関連ノート

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