Methanol → N-cyclohexyl-3,3-dimethoxy-butyramide

HRID 426543

反応式

HRID 426543 の反応式
[CH:1]1([NH:7][C:8](=[O:13])[CH2:9][C:10](=[O:12])[CH3:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:14]([O-])([O-])[O:15]C.[CH3:19]O>C1(C)C=CC(S(O)(=O)=O)=CC=1.N1C2C(=CC=CC=2)C=CC=1>[CH:1]1([NH:7][C:8](=[O:13])[CH2:9][C:10]([O:15][CH3:14])([O:12][CH3:19])[CH3:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

6

反応物 3

HCID 887MethanolHCID 70805N-CyclohexylacetoacetamideHCID 53629101Methylorthoformate

生成物 1

HCID 20390362N-cyclohexyl-3,3-dimethoxy-butyramide

試薬・触媒・溶媒 2

HCID 6101p-Toluenesulfonic acid触媒HCID 7047Quinoline触媒

反応条件

温度
25 °C

実験手順

A mixture of 36.6 g of N-cyclohexyl-acetylacetamide, 32 g of methyl orthoformate, 100 ml of methanol and 1 g of p-toluene sulfonic acid was stirred for 4 hours at 25° C. and after the addition of 2 g of quinoline, the mixture was evaporated to dryness under reduced pressure. The residue was added to isopropyl ether and the mixture was cooled and vacuum filtered. The recovered precipitate was dried to obtain 40 g of N-cyclohexyl-3,3-dimethoxy-butyramide melting at 66° C.

後処理

  1. customthe mixture was evaporated to dryness under reduced pressure
  2. additionThe residue was added to isopropyl ether
  3. temperaturethe mixture was cooled
  4. filtrationvacuum filtered
  5. customThe recovered precipitate was dried

出典と根拠

ORDレコード
ord-0129d5d8f9f04f7ba04bc9fb4c31988a
出典データセット
uspto-grants-1979_10
特許番号
US04170465

関連ノート

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