Iodine → 3-(3-Iodo-2-propynyloxy)-6-methylpyridine
反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([O:8][CH2:9][C:10]#[CH:11])=[CH:4][CH:3]=1.CO.[OH-].[Na+].[I:16]I>O>[I:16][C:11]#[C:10][CH2:9][O:8][C:5]1[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=1参加物
6
実験手順
A solution of 160 g (1.10 moles) 6-methyl-3-(2-propynyloxy) pyridine and 2000 ml methanol was cooled to 0° C. and 750 g 25% sodium hydroxide solution was slowly added. Iodine (362 g. 1.4 moles) was added portionwise and the resulting suspension stirred at 0°-10° C. for an additional 30 min. The reaction mixture was then poured into 4000 ml water and the solids filtered to give 250 g 3-(3-iodo-2-propynyloxy)-6-methylpyridine. Yield=90% Recrystallization from methanol gave analytically pure material, mp 155°-157° C.
後処理
- filtrationthe solids filtered
出典と根拠
- ORDレコード
- ord-9821850cb85d4ed68292e73f4ebdc6ae
- 出典データセット
- uspto-grants-1979_10
- 特許番号
- US04170704
反応ノート
読み込み中…