Hydrochloric Acid → 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine
反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[N:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]#[N:6].[N-:13]=[N+:14]=[N-:15].[Na+].[Cl-].[NH4+].Cl>CN(C)C=O>[N:6]1[NH:13][N:14]=[N:15][C:5]=1[C:4]1[C:3]([C:2]([F:11])([F:1])[F:12])=[N:10][CH:9]=[CH:8][CH:7]=1参加物
6
反応条件
- 温度
- 85 °C
実験手順
A mixture of 2-(trifluoromethyl)nicotinonitrile (0.43 g, 2.50 mmol), sodium azide (0.24 g, 3.75 mmol), and ammonium chloride (0.20 g, 3.75 mmol) in dimethylformamide (2.5 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (20 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine, 0.484 g (90%).
後処理
- temperatureAfter cooling to room temperature
- additionthe reaction mixture was poured onto water (20 mL)
- customThe resulting precipitate was collected
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-e37ea56ca5574a2bafaf368875ccb062
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536203B2
反応ノート
読み込み中…