Water → 5,8-Difluoro-1,4-benzodioxane

HRID 426746

反応式

HRID 426746 の反応式
F[C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]([F:13])[C:3]=1[O:4][CH2:5][CH2:6][OH:7].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:12][C:11]1[C:2]2[O:7][CH2:6][CH2:5][O:4][C:3]=2[C:8]([F:13])=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 27779442-(2,3,6-Trifluorophenoxy)ethanol

生成物 1

HCID 44642425,8-Difluoro-1,4-benzodioxane

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-(2,3,6-Trifluorophenoxy) ethanol (48.8 g, 0.254 mole) and 24 g of anhydrous potassium carbonate in 800 ml of dimethylformamide was refluxed for 20 hours and then poured into water. This was extracted with ether, washed with water, and dried to give 5,8-difluoro-1,4-benzodioxane.

後処理

  1. extractionThis was extracted with ether
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-f8ca3c9a2c7248d7b8e319529edd37db
出典データセット
uspto-grants-1979_10
特許番号
US04171359

関連ノート

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