反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=O)[CH2:6][CH2:5]2.[BH4-].[Na+].S(=O)(=O)(O)O.C1C=CC=CC=1>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:8]([CH:7]=[CH:6][CH2:5]2)=[CH:9][CH:10]=1参加物
6
実験手順
Reduction of 5-bromo-1-indanone E1 with sodium borohydride in MeOH followed by dehydration of the resulting alcohol with sulfuric acid in refluxing benzene at about 80° C. affords 6-bromo-1H-indene E2 (CAS#33065-61-1; see, Young J R, Huang S X, Walsh T F, Wyvratt M J, Yang Y T, Yudkovitz J B, Cui J, Mount G R, Ren R N, Wu T-J, Shen X, Lyons K A, Mao A-H, Carlin J R, Karanam B V, Vincent S H, Cheng K and Goulet M T, Bioorg. Med. Chem. Lett. 2002, 12 (5), 827-832).
出典と根拠
- ORDレコード
- ord-0d8eca445b2e4f0ea9bc68a2e4bf60e2
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536189B2
関連ノート
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