Sodium Hydroxide → 5-Ethyl-2-(2-nitroanilino)thiophene-3-carboxylic acid
反応式
[CH2:1]([C:3]1[S:7][C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])=[C:5]([C:18]([O:20]CC)=[O:19])[CH:4]=1)[CH3:2].[OH-].[Na+]>C(O)C.O>[CH2:1]([C:3]1[S:7][C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])=[C:5]([C:18]([OH:20])=[O:19])[CH:4]=1)[CH3:2]参加物
5
実験手順
Ethyl 5-ethyl-2-(2-nitroanilino)-thiophene-3-carboxylate (6.0 g) dissolved in ethanol (100 ml) and water (50 ml) and heated to 60° C. with stirring. Sodium hydroxide (5 N, 50 ml) was then added and the temperature maintained for 16 hours. The reaction mixture was cooled and diluted with water (500 ml), and solid title product filtered off, m.p. 189°-191° C. (EtOAc).
後処理
- temperaturethe temperature maintained for 16 hours
- temperatureThe reaction mixture was cooled
出典と根拠
- ORDレコード
- ord-af7f29731a024c599811bbb25d66b2d2
- 出典データセット
- uspto-grants-1979_10
- 特許番号
- US04172831
反応ノート
読み込み中…