Methanol → 2,6-Dimethoxy-4-tert-butylphenol

HRID 427114

反応式

HRID 427114 の反応式
[Na].Br[C:3]1[CH:8]=[C:7]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH:6]=[C:5](Br)[C:4]=1[OH:14].CN(C)[CH:17]=[O:18].[CH3:20][OH:21]>>[CH3:20][O:21][C:3]1[CH:8]=[C:7]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH:6]=[C:5]([O:18][CH3:17])[C:4]=1[OH:14]

参加物

5

反応物 4

HCID 887MethanolHCID 6228DimethylformamideHCID 2525182,6-Dibromo-4-tert-butylphenolHCID 5360545Sodium

生成物 1

HCID 106560602,6-Dimethoxy-4-tert-butylphenol収率 89%

実験手順

Sodium (18.2 g, 0.79 g atom) was dissolved in methanol (152 ml). 2,6-Dibromo-4-t-butylphenol (30 g), cuprous bromide (4 g, 0.028 mole) and dimethylformamide (152 ml) were added and the mixture boiled under reflux (88°-84° C.) with stirring for 2 hours. Work up as given in Example 1 gave 2,6-dimethoxy-4-t-butylphenol as a pale yellow oil, 19.9 g of 90% purity (89% yield).

後処理

  1. temperatureunder reflux (88°-84° C.)

出典と根拠

ORDレコード
ord-6fe12f57d5874c38900fc4544c6abd6e
出典データセット
uspto-grants-1979_10
特許番号
US04172960

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