Isobutylamine → Boc-Ile-NH-CH2-CH(CH3)2

HRID 427360

反応式

HRID 427360 の反応式
[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([OH:9])=O)[C@H:3]([CH2:5][CH3:6])[CH3:4].[CH2:17]([NH2:21])[CH:18]([CH3:20])[CH3:19].C1C=CC2N(O)N=NC=2C=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C=O)C>[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([NH:21][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:9])[C@H:3]([CH2:5][CH3:6])[CH3:4]

参加物

6

反応物 4

HCID 6558IsobutylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 2724762tert-Butoxycarbonyl-L-isoleucine

生成物 1

HCID 131722955Boc-Ile-NH-CH2-CH(CH3)2

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In a DMF solution containing 2.0 g of Boc-Ile-OH, 0.82 ml of isobutylamine, 1.27 g of HOBt and 2.06 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture, after filtration, was treated similarly to that in Example 50 (Process 2), except for the crystallization solvent (hexane) to give 1.44 g of the title compound.

後処理

  1. additionwere added under ice cooling
  2. filtrationThe reaction mixture, after filtration
  3. additionwas treated similarly to that in Example 50 (Process 2)

出典と根拠

ORDレコード
ord-f043d0260b1949569a14578a54763201
出典データセット
uspto-grants-2001_11
特許番号
US06313094B1

関連ノート

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