Tert-Butylamine → HCID 131722958、化合物

HRID 427371ノート

反応式

HRID 427371 の反応式
[N:1]1([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:16][C@H:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][C@H:2]1[C:3]([OH:5])=O.[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.Cl>CN(C=O)C>[N:1]1([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:16][C@H:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][C@H:2]1[C:3]([NH:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:5]

参加物

6

反応物 4

HCID 6385Tert-ButylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 11860409Boc-Hyp(Bzl)-OH

生成物 1

HCID 131722958HCID 131722958、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In a DMF solution containing 100 mg of Boc-Hyp(Bzl)-OH, 33 μl of t-butylamine, 48 mg of HOBt and 71 mg of EDC hydrochloride were added and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 33 (Process3) to give 88 mg of the title compound.

後処理

  1. additionwere added
  2. additionThe reaction mixture was treated similarly to that in Example 33 (Process3)

出典と根拠

ORDレコード
ord-c866bb05335d4fc4bd0ddb448c44fef1
出典データセット
uspto-grants-2001_11
特許番号
US06313094B1

反応ノート

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