Nitrogen → 5-(4-Nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-carbaldehyde

HRID 42740

反応式

HRID 42740 の反応式
N#N.[N+:3]([C:6]1[CH:10]=[N:9][N:8]([CH2:11][C:12]2[O:16][C:15]([CH2:17][OH:18])=[CH:14][CH:13]=2)[N:7]=1)([O-:5])=[O:4]>C(C#N)(C)=O.O=[Mn]=O>[N+:3]([C:6]1[CH:10]=[N:9][N:8]([CH2:11][C:12]2[O:16][C:15]([CH:17]=[O:18])=[CH:14][CH:13]=2)[N:7]=1)([O-:5])=[O:4]

参加物

5

反応物 2

HCID 947NitrogenHCID 67365277(5-((4-nitro-2H-1,2,3-triazol-2-yl)methyl)furan-2-yl)methanol

生成物 1

HCID 866494765-(4-Nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-carbaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 694302-Oxopropiononitrile溶媒

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of [5-(4-nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-yl]-methanol (248 mg, 1.11 mmol) in AcCN (11.0 mL) was treated at rt with MnO2 (644 mg, 6.67 mmol). The reaction mixture was stirred at rt overnight before being filtered through Celite and the solvent was removed under reduced pressure. Purification of the residue by FC (40:60 hept-EA) gave the title compound: TLC:rf (40:60 hept-EA)=0.26. LC-MS-conditions 02: tR=0.84 min.

後処理

  1. filtrationbefore being filtered through Celite
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (40:60 hept-EA)

出典と根拠

ORDレコード
ord-3dcb4a5ff9174205af0466bbdc927706
出典データセット
uspto-grants-2013_09
特許番号
US08536209B2

関連ノート

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