Potassium Hydroxide → 4-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine

HRID 427458

反応式

HRID 427458 の反応式
[C:1]([C:3]1[CH:20]=[CH:19][C:6]([O:7][CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9]2)=[CH:5][CH:4]=1)#[N:2].[OH-:21].[K+]>C(O)(C)(C)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9]2)=[CH:19][CH:20]=1)(=[O:21])[NH2:2]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 183570874-[3-(4-Cyanophenoxy)-1-pyrrolidinyl]pyridine

生成物 1

HCID 183571004-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine収率 57.8%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

A mixture of 4-[3-(4-cyanophenoxy)-1-pyrrolidinyl]pyridine (269 mg) and powdered potassium hydroxide (568 mg) in t-butanol (10 ml), under an atmosphere of argon, was heated under reflux for 18 hours. The mixture was filtered hot. The filtercake was washed with water and ethanol to give 4-[3-(4-carbamoylphenoxy)-1-pyrrolidinyl]pyridine (166 mg) as a colourless solid, mp 298-300° C.

後処理

  1. temperatureunder an atmosphere of argon, was heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe mixture was filtered hot
  4. washThe filtercake was washed with water and ethanol

出典と根拠

ORDレコード
ord-1c442b2f30054d8ab9cea61c32b9e4d3
出典データセット
uspto-grants-2001_11
特許番号
US06313127B1

関連ノート

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