Tetrahydrofuran → 8-(2-Ethyl-6-methylbenzylamino)-3-hydroxymethyl-2-methylimidazo(1,2-a)pyridine-6-carboxamide

HRID 427482ノート

反応式

HRID 427482 の反応式
[NH2:1][C:2]([C:4]1[CH:5]=[C:6]([NH:19][CH2:20][C:21]2[C:26]([CH3:27])=[CH:25][CH:24]=[CH:23][C:22]=2[CH2:28][CH3:29])[C:7]2[N:8]([C:10]([C:14](OCC)=[O:15])=[C:11]([CH3:13])[N:12]=2)[CH:9]=1)=[O:3].[BH4-].[Li+].O1CCCC1>CO.O>[CH2:28]([C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([CH3:27])[C:21]=1[CH2:20][NH:19][C:6]1[C:7]2[N:8]([C:10]([CH2:14][OH:15])=[C:11]([CH3:13])[N:12]=2)[CH:9]=[C:4]([C:2]([NH2:1])=[O:3])[CH:5]=1)[CH3:29]

参加物

6

反応物 3

HCID 8028TetrahydrofuranHCID 4148881Lithium borohydride3 回HCID 18357437Ethyl 6-(aminocarbonyl)-8-(2-ethyl-6-methylbenzylamino)-2-methylimidazo[1,2-a]pyridine-3-carboxylate

生成物 1

HCID 97985998-(2-Ethyl-6-methylbenzylamino)-3-hydroxymethyl-2-methylimidazo(1,2-a)pyridine-6-carboxamide収率 46%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒3 回HCID 962Water溶媒

実験手順

Ethyl 6-(aminocarbonyl)-8-(2-ethyl-6-methylbenzylamino)-2-methylimidazo[1,2-a]pyridine-3-carboxylate (280 mg, 0.71 mmol) and lithium borohydride (16 mg, 0.71 mmol) were added to tetrahydrofuran (10 ml) and the reaction mixture was refluxed for 70 min. Additional amounts of lithium borohydride (16 mg) and methanol (45 mg, 1.42 mmol) were added and the mixture was refluxed for 80 min. Additional amounts of lithium borohydride (16 mg) and methanol (22 mg, 71 mmol) were added and the mixture was refluxed for 4 h. The reaction mixture was allowed to reach R.T. and water (1 ml) and methanol (5 ml) and was stirred for 40 min. at R.T. The solvents were evaporated under reduced pressure and the residue was added to water and was stirred for 80 min. The crystals were filtered off and washed with water, ethyl acetate/ethanol and diethyl ether to give the desired product (115 mg, 46%).

後処理

  1. temperaturethe reaction mixture was refluxed for 70 min
  2. temperaturethe mixture was refluxed for 80 min
  3. temperaturethe mixture was refluxed for 4 h
  4. customto reach R.T.
  5. customThe solvents were evaporated under reduced pressure
  6. additionthe residue was added to water
  7. filtrationThe crystals were filtered off
  8. washwashed with water, ethyl acetate/ethanol and diethyl ether

出典と根拠

ORDレコード
ord-feaf4d957cc14c3b8d545d41070b4a4c
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

反応ノート

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