alpha-Chloro-o-xylene → 2,3-Dimethyl-8-(2-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide

HRID 427489

反応式

HRID 427489 の反応式
S(O)(=O)(=O)C.[NH2:6][C:7]1[C:8]2[N:9]([C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=2)[CH:10]=[C:11]([C:13]([NH2:15])=[O:14])[CH:12]=1.Cl[CH2:22][C:23]1[C:24]([CH3:29])=[CH:25][CH:26]=[CH:27][CH:28]=1.C(N(C(C)C)CC)(C)C>CN(C)C=O>[CH3:19][C:17]1[N:18]=[C:8]2[C:7]([NH:6][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[CH3:29])=[CH:12][C:11]([C:13]([NH2:15])=[O:14])=[CH:10][N:9]2[C:16]=1[CH3:20]

参加物

5

反応物 3

HCID 11093alpha-Chloro-o-xyleneHCID 81531DiisopropylethylamineHCID 183574358-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate

生成物 1

HCID 98614262,3-Dimethyl-8-(2-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide収率 13.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate (1.0 g, 2.7 mmol), α-chloro-o-xylene (0.38 g, 2.7 mmol) and diisopropylethylamin (0.76 g, 5.9 mmol) in dimethylformamide (7 ml) were stirred at 50° C. for 7 h and at room temperature for 72 h. The solvent was evaporated and the residue was treated with a mixture of methylene chloride, water and a small amount of diisopropylethylamin. The solid that formed was isolated by filtration and washed with ethylacetate to give 0.11 g (13%) of the title compound.

後処理

  1. customThe solvent was evaporated
  2. additionthe residue was treated with a mixture of methylene chloride, water
  3. customThe solid that formed
  4. customwas isolated by filtration
  5. washwashed with ethylacetate

出典と根拠

ORDレコード
ord-5fce369b50d845558544c18f95a8161d
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

関連ノート

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