Water → 2,3-Dimethyl-8-(2,6-dimethylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide

HRID 427491

反応式

HRID 427491 の反応式
S(O)(=O)(=O)C.[NH2:6][C:7]1[C:8]2[N:9]([C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=2)[CH:10]=[C:11]([C:13]([NH2:15])=[O:14])[CH:12]=1.[CH2:21]([C:23]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31]C)[C:24]=1[CH2:25]Cl)C.C(N(C(C)C)CC)(C)C.O>CN(C)C=O.C(Cl)Cl>[CH3:19][C:17]1[N:18]=[C:8]2[C:7]([NH:6][CH2:25][C:24]3[C:27]([CH3:31])=[CH:28][CH:29]=[CH:30][C:23]=3[CH3:21])=[CH:12][C:11]([C:13]([NH2:15])=[O:14])=[CH:10][N:9]2[C:16]=1[CH3:20]

参加物

7

反応物 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 183574358-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylateHCID 183574492-(Chloromethyl)-1,3-diethylbenzene

生成物 1

HCID 97972452,3-Dimethyl-8-(2,6-dimethylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide収率 53.3%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

実験手順

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate (4.0 g, 10.7 mmol), 2,6-diethylbenzylchloride (1.8 g, 9.9 mmol), diisopropylethylamin (3.0 g, 23.3 mmol) were stirred in dimethylformamide (20 ml) at 50° C. overnight and at 70° C. for 3 h. Water (60 ml) and methylene chloride were added and the organic layer was separated, dried and evaporated under reduced pressure. The residue was treated with diethyl ether and the product was filtred off to give 1.7 g (45%) of the title compound.

後処理

  1. customthe organic layer was separated
  2. customdried
  3. customevaporated under reduced pressure
  4. additionThe residue was treated with diethyl ether

出典と根拠

ORDレコード
ord-80d10fb4fbbf4e17b0dd803562336d9d
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

関連ノート

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