Methyl 6-amino-5-nitropyridine-3-carboxylate → Methyl 5,6-diaminopyridine-3-carboxylate

HRID 427498ノート

反応式

HRID 427498 の反応式
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[H][H]>[Pd].CO>[NH2:12][C:11]1[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

参加物

5

反応物 2

HCID 13768248Methyl 6-amino-5-nitropyridine-3-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 9920476Methyl 5,6-diaminopyridine-3-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Methyl 6-amino-5-nitronicotinate (9.0 g, 46 mmol) and a small amount of Pd/C cat. were added to methanol (200 ml) and the mixture was hydrogenated at room temperature and atmospheric pressure until the uptake of hydrogen ceased. Following filtration through celite, the methanol was evaporated under reduced pressure to give the title compound, 7.0 g (92%).

後処理

  1. customwas hydrogenated at room temperature
  2. filtrationfiltration through celite
  3. customthe methanol was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-02d92824d41e468fa86f2ba63b09f304
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

反応ノート

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