Thionyl Chloride → 2-Isopropyl-6-methylbenzylchloride

HRID 427512ノート

反応式

HRID 427512 の反応式
[CH:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:5]=1[CH2:6]O)([CH3:3])[CH3:2].S(Cl)([Cl:15])=O>C(Cl)Cl>[CH:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:5]=1[CH2:6][Cl:15])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 18357444(2-Isopropyl-6-methylphenyl)methanol

生成物 1

HCID 183574432-Isopropyl-6-methylbenzylchloride収率 96.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-isopropyl-6-methylbenzylalcohol (1.7 g, 10.4 mmol) in methylene chloride (20 ml) was added thionyl chloride (1.7 g, 14 mmol) and the reaction was stirred for 1 h. at room temperature. The solvent was evaporated under reduced pressure and the residue was filrated through silica gel using methylenechloride as eluent. The solvent was evaporated under reduced pressure to give 1.83 g (96%) of the title compound as an oil.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3aa176b262cf453884f4ed0481d82783
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

反応ノート

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