Sodium Hydroxide → 6-[(Pyridin-2-yl)methoxy]pyridin-3-amine

HRID 427722ノート

反応式

HRID 427722 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][CH:9]=1)([O-])=O.[Sn](Cl)Cl.[OH-].[Na+]>C(O)C.Cl.O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][CH:9]=1

参加物

7

反応物 3

HCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 183577252-(Pyridin-2-ylmethoxy)-5-nitropyridine

生成物 1

HCID 154477886-[(Pyridin-2-yl)methoxy]pyridin-3-amine収率 78%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

5-Nitro-2-(pyridin-2-ylmethyloxy)pyridine (D1, 2.0 g, 0.0087 mole) in ethanol (70 ml) was treated with tin (II) chloride (8.3 g, 0.044 mole) in conc. HCl (15 ml). The mixture was heated to 50° C. for 0.5 hour. After cooling to room temperature, the mixture was diluted with water, basified with 10% aqueous sodium hydroxide solution, extracted into ethyl acetate, dried (Na2SO4) and evaporated in vacuo to afford the title compound (1.36 g, 78%) as a brown oil.

後処理

  1. temperatureAfter cooling to room temperature
  2. extractionextracted into ethyl acetate
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-19bdabcaa6ba44608332a5b83fb7d5f1
出典データセット
uspto-grants-2001_11
特許番号
US06313145B1

反応ノート

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