Allyl bromide → 2-Allyloxy-5-bromobenzoic acid

HRID 427744ノート

反応式

HRID 427744 の反応式
[Br:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.C(=O)([O-])[O-:12].[K+].[K+].[CH2:17](Br)[CH:18]=[CH2:19]>CN(C=O)C>[CH2:17]([O:10][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=1[C:7]([OH:12])=[O:8])[CH:18]=[CH2:19]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 728635-Bromosalicylaldehyde

生成物 1

HCID 87071652-Allyloxy-5-bromobenzoic acid収率 41%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 5-bromo-salicylaldehyde (20.1 g, 100 mM) in DMF (50 ml) was treated with potassium carbonate (20.7 g, 150 mM) and allyl bromide (12.7 g, 10.5 mM). The reaction was stirred at ambient temperature for 18 hours. The reaction was partitioned between ethyl acetate/water. The organic phase was washed with water four times, dried (MgSO4) and evaporated at reduced pressure to give 2-allyloxy-5-bromobenzoic acid as a pale yellow oil (10.0 g, 41 %).

後処理

  1. customThe reaction was partitioned between ethyl acetate/water
  2. washThe organic phase was washed with water four times
  3. dry with materialdried (MgSO4)
  4. customevaporated at reduced pressure

出典と根拠

ORDレコード
ord-6a6fe4789a62481b87e7327836099939
出典データセット
uspto-grants-2001_11
特許番号
US06313148B1

反応ノート

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