Indole → 1H-Indole, 1-(1-methoxyethyl)-
反応式
[H-].[Na+].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4]1.Cl[CH:13]([O:15][CH3:16])[CH3:14]>CN(C=O)C>[CH3:16][O:15][CH:13]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4]1)[CH3:14]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a suspension of NaH (1.92 gm of a 60% dispersion in oil) in 75 mL of DMF was added indole (4.68 gm, 40 mmol) (Aldrich). The mixture was stirred for 15 minutes at 0° C., and 1-chloroethyl methylether (4 mL) was added dropwise. The resulting mixture was stirred at 0° C. for 1 hour and poured over ice/water, and extracted with toluene. The organic layer was dried over magnesium sulfate, and evaporated. The residue was purified by flash chromatography using EtOAc/hexanes to give 4 gm of 1-[1-methoxyethyl]indole. (Yield 58%).
後処理
- stirringThe resulting mixture was stirred at 0° C. for 1 hour
- extractionextracted with toluene
- dry with materialThe organic layer was dried over magnesium sulfate
- customevaporated
- customThe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-fda5e46a6cce4fcdb4ebce9c540d39c0
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06313143B1
反応ノート
読み込み中…