Nitrogen → 1-(4-Chloromethyl-thiazol-2-yl)ethanone

HRID 42796

反応式

HRID 42796 の反応式
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]([OH:12])[CH3:11])[S:8][CH:9]=1>C(C#N)(C)=O.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([C:10](=[O:12])[CH3:11])[S:8][CH:9]=1

参加物

5

反応物 2

HCID 947NitrogenHCID 668198411-(4-Chloromethyl-thiazol-2-yl)-ethanol

生成物 1

HCID 668199771-(4-Chloromethyl-thiazol-2-yl)ethanone

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 694302-Oxopropiononitrile溶媒

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(4-chloromethyl-thiazol-2-yl)-ethanol (1.09 g, 6.15 mmol) in AcCN (61.0 mL) was treated at rt with MnO2 (2.97 g, 30.76 mmol) and the reaction mixture was stirred for 16 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.84 min, [M+H]+=176.41.

後処理

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-182df11f68794eaba278d087ecf90f25
出典データセット
uspto-grants-2013_09
特許番号
US08536209B2

関連ノート

読み込み中…