Nitrogen → 5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazole-3-carbaldehyde

HRID 42814

反応式

HRID 42814 の反応式
N#N.[C:3]([SiH2:7][O:8][C:9]([CH3:18])([CH3:17])[C:10]1[O:14][N:13]=[C:12]([CH2:15][OH:16])[CH:11]=1)([CH3:6])([CH3:5])[CH3:4]>C(C#N)(C)=O.O=[Mn]=O>[C:3]([SiH2:7][O:8][C:9]([CH3:18])([CH3:17])[C:10]1[O:14][N:13]=[C:12]([CH:15]=[O:16])[CH:11]=1)([CH3:6])([CH3:4])[CH3:5]

参加物

5

反応物 2

HCID 947NitrogenHCID 131730844[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-methanol

生成物 1

HCID 1317308465-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazole-3-carbaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 694302-Oxopropiononitrile溶媒

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of [5-(tert-butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-methanol (2.94 g, 12.08 mmol) in AcCN (120.0 mL) was treated at rt with MnO2 (8.17 g, 84.56 mmol) and the reaction mixture was stirred for 24 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil: TLC:rf (9:1 hept-EA)=0.32. LC-MS-conditions 02: tR=0.92 min.

後処理

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-4b8f9c0889454eae8fb7784dd72b7cc0
出典データセット
uspto-grants-2013_09
特許番号
US08536209B2

関連ノート

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