Water → 5-(2-Chloroethyl)Oxindole

HRID 428254ノート

反応式

HRID 428254 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.C([SiH](CC)CC)C.O>FC(F)(F)C(O)=O>[Cl:1][CH2:2][CH2:3][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2

参加物

5

反応物 3

HCID 962WaterHCID 12052TriethylsilaneHCID 20605765-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 145813925-(2-Chloroethyl)Oxindole収率 65%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

5-Chloroacetyl-2-oxindole(4.18 g) in 30 mL of trifluoroacetic acid in an ice bath was treated with 4.65 g of triethylsilane and stirred at room temperature for 3 hours. The mixture was poured into 150 mL of water and the precipitate collected by vacuum filtration, washed with 50 mL of water and dried to give 2.53 g (65% yield) of 5-(2-chloroethyl)-2-oxindole as a reddish-brown solid.

後処理

  1. filtrationthe precipitate collected by vacuum filtration
  2. washwashed with 50 mL of water
  3. customdried

出典と根拠

ORDレコード
ord-73c7bd99807c47bbb53c5d490f218ea1
出典データセット
uspto-grants-2001_11
特許番号
US06313158B1

反応ノート

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