Hydrogen Peroxide → N,N-Diisopropyl-3-carbamoyl-3-phenylpropanamide

HRID 428341ノート

反応式

HRID 428341 の反応式
[CH:1]([N:4]([CH:17]([CH3:19])[CH3:18])[C:5](=[O:16])[CH2:6][CH:7]([C:14]#[N:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:3])[CH3:2].[OH:20]O>CCO.[OH-].[Na+]>[CH:17]([N:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:16])[CH2:6][CH:7]([C:14](=[O:20])[NH2:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:19])[CH3:18]

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 18357355N,N-Diisopropyl-3-cyano-3-phenylpropanamide

生成物 1

HCID 18357397N,N-Diisopropyl-3-carbamoyl-3-phenylpropanamide

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

N,N-Diisopropyl-3-cyano-3-phenylpropanamide (21.1 g, 82 mmol) was dissolved in EtOH (130 mL) and 2 M NaOH (100 mL). Hydrogen peroxide (30%, 20.2 mL, 200 mmol) was added and the mixture was stirred at ambient temperature for two hours. The resulting precipitate was filtered, washed with water and dried, yielding the title compound as white crystals, 15.6 g (69%): 1H NMR (CDCl3) δ1.09 (d, 3H), 1.19 (d, 3H), 1.31 (m, 6H), 2.51 (dd, 1H), 3.30 (dd, 1H), 3.41 (m, 1H), 4.02 (m, 1H), 4.18 (dd, 1H), 5.7 (br, 1H), 6.4 (br, 1H), 7.21-7.42 (m, 5H).

後処理

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-1056e1efe18f4c79ab3264c2884f9206
出典データセット
uspto-grants-2001_11
特許番号
US06313132B1

反応ノート

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