3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one → HCID 178486575、化合物

HRID 428617

反応式

HRID 428617 の反応式
C([N:8]1[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:10]1[CH:11]=[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)[N:8]=[CH:9]1

参加物

4

反応物 1

HCID 184052653-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one

生成物 1

HCID 178486575HCID 178486575、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one (1.1 g) is dissolved in ethanol (90 ml). The reaction solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst for 7 hours. The mixture is filtered to remove the catalyst, and the filtrate is evaporated under reduced pressure. The product is converted to its hydrochloride salt in ethyl acetate using dry hydrochloric acid. The yield is 0.6 g, m.p. 258-261° C.

後処理

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ee120878f08745b19a7414a1108d4a3f
出典データセット
uspto-grants-2001_11
特許番号
US06313311B1

関連ノート

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