Sodium Iodide → 1-Benzyloxy-2-iodoethane
反応式
BrC1C=CC(S(O[CH2:12][CH2:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=O)=O)=CC=1.[I-:22].[Na+]>CC(C)=O>[I:22][CH2:12][CH2:13][O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1参加物
4
実験手順
To a solution of (benzyloxy)ethyl 4-bromobenzenesulfonate (Preparation 89, 6.92 g, 19.5 mmol) in acetone (60 ml) was added sodium iodide (5.84 g, 39.0 mmol) and the reaction mixture was left to stir at room temperature for 16 h. The resulting precipitate was filtered and the filtrate was concentrated in vacuo. The crude residue was dissolved in dichloromethane and washed with aqueous sodium thiosulphate solution and then with water (2×60 ml). The organic layer was dried (Na2SO4) and concentrated in vacuo to give the title compound as a pale brown oil (4.5 g, 88%).
後処理
- waitthe reaction mixture was left
- filtrationThe resulting precipitate was filtered
- concentrationthe filtrate was concentrated in vacuo
- dissolutionThe crude residue was dissolved in dichloromethane
- washwashed with aqueous sodium thiosulphate solution
- dry with materialThe organic layer was dried (Na2SO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-4e03dfb26ace47de9bf4efe08ebfb3c6
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06313312B1
反応ノート
読み込み中…