Hydrochloric Acid → 3-(3-Fluorophenoxy)propanoic acid

HRID 429055

反応式

HRID 429055 の反応式
[OH-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1.Br[CH2:12][CH2:13][C:14]([OH:16])=[O:15].Cl>O>[F:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:12][CH2:13][C:14]([OH:16])=[O:15]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 97433-FluorophenolHCID 115533-Bromopropionic acidHCID 14798Sodium Hydroxide

生成物 1

HCID 150860153-(3-Fluorophenoxy)propanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of sodium hydroxide (6.7 gm, 167 mmol) in water (20 mL) was added slowly to a neat mixture of 3-fluorophenol (8.9 gm, 79.5 mmol) and 3-bromopropionic acid (12.26 gm,80 mmol) as the reaction became exothermic. The mixture was refluxed gently for two hours and then allowed to cool and become semi-solid. Water was added to dissolve the semi-solid and then was acidified with concentrated HCl. The product was extracted into diethyl ether and the ethereal extract was dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was slurried in 4:1 hexanetbenzene to give crystalline 3-(3-fluorophenoxy) propionic acid. m.p.: 90-91° C.

後処理

  1. temperatureThe mixture was refluxed gently for two hours
  2. temperatureto cool
  3. dissolutionto dissolve the semi-solid
  4. extractionThe product was extracted into diethyl ether
  5. extractionthe ethereal extract
  6. dry with materialwas dried over anhydrous magnesium sulfate
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-81a6494de2414bae9f8d97f8e2860d52
出典データセット
uspto-grants-2001_11
特許番号
US06316437B1

関連ノート

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