2,4-Dinitroaniline → 2-Bromo-4,6-dinitroaniline

HRID 429577

反応式

HRID 429577 の反応式
[N+:1]([C:4]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].[Br:14]Br>CC(O)=O.CCOC(C)=O>[N+:1]([C:4]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([Br:14])[C:5]=1[NH2:6])([O-:3])=[O:2]

参加物

5

反応物 2

HCID 73212,4-DinitroanilineHCID 24408Bromine

生成物 1

HCID 157522-Bromo-4,6-dinitroaniline収率 92%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2,4-dinitroaniline (2.2 g, 12 mmol) in 40 ml of AcOH was added 1.0 ml of Br2 dropwise and reaction mixture was stirred for 1 h. The reaction mixture was concentrated in vacua, yielding a dark residue which was diluted with EtOAc and washed with aqueous NaHCO3. Organic layer was dried over MgSO4 and concentrated in vacuo to provide 2.9 g (11 mmol, 92%) of 2,4-dinitro-6-bromo-aniline which was characterized by NMR and used in a following reaction without further purification.

後処理

  1. customreaction mixture
  2. concentrationThe reaction mixture was concentrated in vacua
  3. customyielding a dark residue which
  4. washwashed with aqueous NaHCO3
  5. dry with materialOrganic layer was dried over MgSO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-bde4e98607de4456a69db25611a525f3
出典データセット
uspto-grants-2001_11
特許番号
US06316637B1

関連ノート

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