2,4-Dinitroaniline → 2-Bromo-4,6-dinitroaniline
反応式
[N+:1]([C:4]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].[Br:14]Br>CC(O)=O.CCOC(C)=O>[N+:1]([C:4]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([Br:14])[C:5]=1[NH2:6])([O-:3])=[O:2]参加物
5
実験手順
To a solution of 2,4-dinitroaniline (2.2 g, 12 mmol) in 40 ml of AcOH was added 1.0 ml of Br2 dropwise and reaction mixture was stirred for 1 h. The reaction mixture was concentrated in vacua, yielding a dark residue which was diluted with EtOAc and washed with aqueous NaHCO3. Organic layer was dried over MgSO4 and concentrated in vacuo to provide 2.9 g (11 mmol, 92%) of 2,4-dinitro-6-bromo-aniline which was characterized by NMR and used in a following reaction without further purification.
後処理
- customreaction mixture
- concentrationThe reaction mixture was concentrated in vacua
- customyielding a dark residue which
- washwashed with aqueous NaHCO3
- dry with materialOrganic layer was dried over MgSO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-bde4e98607de4456a69db25611a525f3
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06316637B1
反応ノート
読み込み中…