Thionyl Chloride → 3-(Tribromomethanesulfonyl)benzoyl chloride

HRID 429600ノート

反応式

HRID 429600 の反応式
[Br:1][C:2]([Br:16])([Br:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9](O)=[O:10])(=[O:5])=[O:4].S(Cl)([Cl:19])=O>CN(C)C=O>[Br:1][C:2]([Br:16])([Br:15])[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[C:9]([Cl:19])=[O:10])(=[O:5])=[O:4]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 224660403-(Tribromomethanesulfonyl)benzoic acid

生成物 1

HCID 224660413-(Tribromomethanesulfonyl)benzoyl chloride収率 94%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 375 g (0.86 mole) of 3-tribromomethanesulfonyl benzoic acid were added 1 ml of dimethylformamide and 500 ml of thionyl chloride and the mixture was refluxed for one hour. The reaction mixture was filtered and 3000 ml of hexane was added to the filtrate to precipitate crystals. The crystals were recovered by filtration and dried to obtain 366 g of 3-tribromomethanesulfonyl benzoylchloride (yield 94%, white crystals).

後処理

  1. temperaturethe mixture was refluxed for one hour
  2. filtrationThe reaction mixture was filtered
  3. addition3000 ml of hexane was added to the filtrate
  4. customto precipitate crystals
  5. filtrationThe crystals were recovered by filtration
  6. customdried

出典と根拠

ORDレコード
ord-2336afc0a2eb4eaf962cbc5d70731440
出典データセット
uspto-grants-2001_11
特許番号
US06316670B1

反応ノート

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