Triethylamine → 2-Phenyl-4-(2-methylphenyl)cyclohexanone oxime

HRID 429719ノート

反応式

HRID 429719 の反応式
[C:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])[CH2:10][CH2:9][C:8]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl.[NH2:29][OH:30]>CO.C(Cl)Cl>[C:1]1([CH:7]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])[CH2:10][CH2:9][C:8]2=[N:29][OH:30])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 18352673HCID 18352673、化合物

生成物 1

HCID 867506802-Phenyl-4-(2-methylphenyl)cyclohexanone oxime収率 59%

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

2-Phenyl-4-(2-methylphenyl)cyclohexanone, 13.1 grams (49.5 mmol), was dissolved in 200 mL methanol/methylene chloride, followed by 11.1 mL (79.3 mmol) triethylamine and 5.5 grams (79.3 mmol) hydroxylamine hydrochloride. The solution was stirred at room temperature for 48 hours, the solvent evaporated, and the resulting solid washed with methanol and dried to afford 8.2 grams (59%) of a yellow solid.

後処理

  1. customthe solvent evaporated
  2. washthe resulting solid washed with methanol
  3. customdried

出典と根拠

ORDレコード
ord-c21031604a664fc4a4ada417b0320005
出典データセット
uspto-grants-2001_11
特許番号
US06319915B1

反応ノート

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