tert-Butyl methyl ether → HCID 178435105、化合物
反応式
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8]CC([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=O.C[O:18][C:19](C)(C)[CH3:20]>C(O)C>[Br-:8].[SH:13]1([C:19](=[O:18])[CH2:20][N+:3]2[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1参加物
5
実験手順
A solution of 4,5-dimethylthiazole (2,2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.
後処理
- customThe white product separated
- filtrationwas filtered
- customdried
- customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.
出典と根拠
- ORDレコード
- ord-07544ed515c34ce68a593ce274f675ff
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06319934B1
反応ノート
読み込み中…