tert-Butyl methyl ether → HCID 178435105、化合物

HRID 429786

反応式

HRID 429786 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8]CC([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=O.C[O:18][C:19](C)(C)[CH3:20]>C(O)C>[Br-:8].[SH:13]1([C:19](=[O:18])[CH2:20][N+:3]2[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1

参加物

5

反応物 3

HCID 15413tert-Butyl methyl etherHCID 625104,5-DimethylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

生成物 1

HCID 178435105HCID 178435105、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4,5-dimethylthiazole (2,2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

後処理

  1. customThe white product separated
  2. filtrationwas filtered
  3. customdried
  4. customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

出典と根拠

ORDレコード
ord-07544ed515c34ce68a593ce274f675ff
出典データセット
uspto-grants-2001_11
特許番号
US06319934B1

関連ノート

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