Ammonia → N-(Phenylmethyl)thiourea

HRID 429798

反応式

HRID 429798 の反応式
[CH2:1]([N:8]=[C:9]=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:11].O>C1COCC1>[CH2:1]([NH:8][C:9]([NH2:11])=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 962WaterHCID 2346Benzyl Isothiocyanate

生成物 1

HCID 737375N-(Phenylmethyl)thiourea収率 108.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

96.3 g (366 mmoles) of benzylisothiocyanate were dissolved in 100 ml o THF and treated with 44.2 ml (732 mmoles) of 32% ammonia solution After 0.5 hour at 40-45° C., 300 ml of water were added and the THF removed in vacuo. The gummy suspension is treated with 200 ml of ether, the crystals collected and washed with water and ether. Suspension in 30 ml of methylenechloride and collection gave 65.77 g (64.2%) of benzyl-2-thiourea with mp 144-5° C.

後処理

  1. customthe THF removed in vacuo
  2. additionThe gummy suspension is treated with 200 ml of ether
  3. customthe crystals collected
  4. washwashed with water and ether
  5. customSuspension in 30 ml of methylenechloride and collection

出典と根拠

ORDレコード
ord-ba70aae2e066437bb64b17f50dc28c49
出典データセット
uspto-grants-2001_11
特許番号
US06319928B1

関連ノート

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