Methyl iodide → 8-(2-Chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide

HRID 4298ノート

反応式

HRID 4298 の反応式
[CH3:1][I:2].[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][O:7][C:8]1[C:9]2[N:10]([C:14]([CH2:18][N:19]([CH3:21])[CH3:20])=[C:15]([CH3:17])[N:16]=2)[CH:11]=[CH:12][CH:13]=1>CC(C)=O>[I-:2].[Cl:3][C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][O:7][C:8]1[C:9]2[N:10]([C:14]([CH2:18][N+:19]([CH3:1])([CH3:21])[CH3:20])=[C:15]([CH3:17])[N:16]=2)[CH:11]=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 138259368-(2-Chlorobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine

生成物 1

HCID 138259378-(2-Chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide収率 101.7%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Methyl iodide (3.48 g) was added dropwise to a solution of 8-(2-chlorobenzyloxy)-3-dimethylaminomethyl-2-methylimidazo[1,2-a]pyridine (7.8 g) in acetone (100 ml) at room temperature and the mixture was stirred for 24 hours. The resulting precipitate was collected by filtration, washed with acetone, and dried in a desiccator to give 8-(2-chlorobenzyloxy)-3-trimethylammoniomethyl-2-methylimidazo[1,2-a]pyridine iodide (11.35 g).

後処理

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with acetone
  3. customdried in a desiccator

出典と根拠

ORDレコード
ord-91c2eee7c15b45b0a59d06a37df37e76
出典データセット
uspto-grants-1988_02
特許番号
US04725601

反応ノート

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