Sodium Hydroxide → 4-(2-pyridinyl)-1-Piperidinepropanamine

HRID 429954ノート

反応式

HRID 429954 の反応式
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][NH2:26])[CH2:19][CH2:18]1.[OH-].[Na+]>>[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]1[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][CH2:25][NH2:26])[CH2:21][CH2:22]1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 701512003-[4-(2-Pyridyl)piperidin-1-yl]propylamine l-tartrate salt

生成物 1

HCID 101768154-(2-pyridinyl)-1-Piperidinepropanamine

実験手順

3-[4-(2-pyridyl)piperidin-1-yl]propylamine L-tartrate salt, (7), (1120 g, 3.0 mol) was treated with 5M NaOH (5.7 L, 28.6 mol). The suspension was extracted with isopropyl acetate (3×18 L). The combined extracts were concentrated to afford 3-[4-(2-pyridyl)-piperidin-1-yl]propylamine, (6), as a viscous oil.

後処理

  1. extractionThe suspension was extracted with isopropyl acetate (3×18 L)
  2. concentrationThe combined extracts were concentrated

出典と根拠

ORDレコード
ord-1bf3103c9ce04e95aba3cb58e74e6f54
出典データセット
uspto-grants-2001_11
特許番号
US06320049B1

反応ノート

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