Hydrochloric Acid → 5-Hydroxybenzo[b]thiophene-3-carboxylic acid
反応式
C1(S([O:10][C:11]2[CH:22]=[CH:21][C:14]3[S:15][CH:16]=[C:17]([C:18]([OH:20])=[O:19])[C:13]=3[CH:12]=2)(=O)=O)C=CC=CC=1.Cl>[OH-].[Na+]>[OH:10][C:11]1[CH:22]=[CH:21][C:14]2[S:15][CH:16]=[C:17]([C:18]([OH:20])=[O:19])[C:13]=2[CH:12]=1参加物
4
反応条件
- 温度
- 40 °C
実験手順
5-Benzenesulfonyloxybenzo[b]thiophene-3-carboxylic acid (6) (100 mg, 0.3 mmol) prepared in Examples above was dissolved in 1 N sodium hydroxide (1.2 ml) and heated at 40° C. for 8 hours with stirring. To the reaction solution was added 1 N hydrochloric acid (1.2 ml), and the deposited crystals were filtered, washed with water and dried to provide 58 mg of the title compound (11). Yield: 96.6% mp 262-263° C.
後処理
- filtrationthe deposited crystals were filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-9601a2d7d43f4dc484f5e8fd3159abc4
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06320060B1
反応ノート
読み込み中…