Water → HCID 15450533、化合物
反応式
[OH:1][C:2]1[CH:13]=[CH:12][C:5]2[S:6][CH:7]=[C:8]([C:9]([OH:11])=[O:10])[C:4]=2[CH:3]=1.SC1C=C[C:18]([OH:21])=[CH:17]C=1.N1C=CC=CC=1.O>C(OC(=O)C)(=O)C>[C:18]([O:1][C:2]1[CH:13]=[CH:12][C:5]2[S:6][CH:7]=[C:8]([C:9]([OH:11])=[O:10])[C:4]=2[CH:3]=1)(=[O:21])[CH3:17]参加物
6
実験手順
5-Hydroxybenzo[b]thiophene-3-carboxylic acid (11) (1,140 mg) prepared in above (1) was dissolved in acetic anhydride (2 ml), pyridine (4 ml). After 3 hours, water was added and the mixture was continuously stirred under ice-cooling for 1.5 hours. The deposited crystals were filtered, washed with water and dried to provide 1,349 mg of the title compound (12). Yield: 97.3% mp 239-240° C.
後処理
- temperaturecooling for 1.5 hours
- filtrationThe deposited crystals were filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-bb7122f3c79c4dcfa0ea80bd2e8efda1
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06320060B1
反応ノート
読み込み中…