Dimethylformamide → HCID 45358729、化合物

HRID 430025ノート

反応式

HRID 430025 の反応式
CN(C)C=O.[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][C:14]([NH:16][CH2:17][C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)=[O:15])[CH:7]=1.C(Cl)(=O)C([Cl:30])=O>C1(C)C=CC=CC=1>[ClH:30].[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][C:14]([NH:16][CH2:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([Cl:30])=[O:23])=[CH:20][CH:19]=2)=[O:15])[CH:7]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 98173384-((((Pyridin-3-ylmethoxy)carbonyl)amino)methyl)benzoic acid

生成物 1

HCID 45358729HCID 45358729、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

0.8 ml of N,N-dimethylformamide was added to a toluene suspension (2000 ml) including 40 g (0.14 mole) of 4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzoic acid. Then, 24 ml of oxalyl chloride were added dropwise to the resultant mixture, followed by stirring for 4 hours. A deposited white solid was collected by filtration to obtain 47.7 g (quantitative) of 4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzoyl chloride hydrochloride.

後処理

  1. filtrationA deposited white solid was collected by filtration

出典と根拠

ORDレコード
ord-898a6c29c20842dbabb4a77f9eee5138
出典データセット
uspto-grants-2001_11
特許番号
US06320078B1

反応ノート

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