Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 430593ノート

反応式

HRID 430593 の反応式
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.C(Cl)Cl>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

生成物 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid, 84 g of oxalyl chloride and a few drops of dimethylformamide in 930 ml of dry methylene chloride are stirred at room temperature for 5 hours. The reaction mixture is concentrated by evaporation and the residue is distilled in vacuo.

後処理

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. distillationthe residue is distilled in vacuo

出典と根拠

ORDレコード
ord-2b89adf6c891449e8baa063d8a6962d8
出典データセット
uspto-grants-2001_11
特許番号
US06323213B1

反応ノート

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