1,1'-Carbonyldiimidazole → Ethyl 1-(Benzofuran-3-ylacety)-4-piperidinecarboxylate

HRID 430600ノート

反応式

HRID 430600 の反応式
C(N1C=CN=C1)(N1C=CN=C1)=O.[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([CH2:22][C:23]([OH:25])=O)=[CH:14]1.[NH:26]1[CH2:31][CH2:30][CH:29]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:28][CH2:27]1>ClCCl>[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([CH2:22][C:23]([N:26]2[CH2:31][CH2:30][CH:29]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:28][CH2:27]2)=[O:25])=[CH:14]1

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 70770Ethyl 4-piperidinecarboxylateHCID 27629402-(1-Benzofuran-3-yl)acetic acid

生成物 1

HCID 15512383Ethyl 1-(Benzofuran-3-ylacety)-4-piperidinecarboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

22 g of carbonyldiimidazole are added in portions to 23.9 g of benzofuran-3-ylacetic acid in 250 ml of dichloromethane. When the evolution of gas has stopped, the reaction mixture is stirred for 1 hour and then 21 ml of ethyl piperid-4-ylcarboxylate are added dropwise. After 12 hours' stirring at room temperature, the reaction mixture is washed with 1N sodium hydroxide solution and then with 1N hydrochloric acid. After decanting and drying, concentration under reduced pressure enables the expected product to be isolated.

後処理

  1. stirringAfter 12 hours' stirring at room temperature
  2. washthe reaction mixture is washed with 1N sodium hydroxide solution
  3. customAfter decanting
  4. customdrying
  5. concentrationconcentration under reduced pressure
  6. customto be isolated

出典と根拠

ORDレコード
ord-519d9fcff93846d8911cd7f7fac2334c
出典データセット
uspto-grants-2001_11
特許番号
US06323217B2

反応ノート

読み込み中…