Ammonium Hydroxide → 4-Bromo-5-nitroisoquinoline

HRID 430615

反応式

HRID 430615 の反応式
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[N+:12]([O-])([O-:14])=[O:13].[K+].[OH-].[NH4+]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[N+:12]([O-:14])=[O:13])[CH:5]=[N:4][CH:3]=1

参加物

5

反応物 3

HCID 14923Ammonium HydroxideHCID 24434Potassium NitrateHCID 737434-Bromoisoquinoline

生成物 1

HCID 2712804-Bromo-5-nitroisoquinoline

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

Add 11 g of 4-bromoisoquinoline to 45 ml of sulphuric acid, followed, dropwise, by a solution of 9.1 g of potassium nitrate in 45 ml of sulphuric acid whilst cooling in an ice-bath. The reaction mixture is stirred at room temperature for 2 hours 30, before being poured onto ice. After the resulting solution has been rendered basic with ammonium hydroxide, the crystals are filtered off, washed and dried to yield the expected product.

後処理

  1. additionbefore being poured onto ice
  2. filtrationthe crystals are filtered off
  3. washwashed
  4. customdried

出典と根拠

ORDレコード
ord-b2b2a7b55cf246a59559dfaa0a888bd2
出典データセット
uspto-grants-2001_11
特許番号
US06323217B2

関連ノート

読み込み中…