Hydrazine hydrate (1:1) → 3-phenyl-1H-indole-2-carbohydrazide
反応式
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]([O:18]CC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:22][NH2:23]>C(O)C>[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]([NH:22][NH2:23])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
A solution of Example 1B (2.65 g, 10 mmol) in ethanol (20 mL) was treated with hydrazine hydrate (3.12 mL, 100 mmol), heated to reflux for 18 hours, cooled to room temperature, and filtered. The resulting solid was washed with ethanol and dried under vacuum to provide 1.86 g (74%) of the desired product of sufficient purity for subsequent use.
後処理
- temperatureheated
- temperatureto reflux for 18 hours
- filtrationfiltered
- washThe resulting solid was washed with ethanol
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-8fb8d2c02ae042de967bb2addb26a35b
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06323228B1
反応ノート
読み込み中…