Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-, methyl ester → HCID 11833211、化合物

反応式

[C:1]([C:5]1[CH:6]=[C:7]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH:8]=[CH:9][C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].O.[C:19](O)(=[O:22])[CH:20]=[O:21]>ClCCCl.C1(C)C=CC(S(O)(=O)=O)=CC=1>[C:1]([C:5]1[C:10]2[O:11][C:20](=[O:21])[CH:19]([OH:22])[C:9]=2[CH:8]=[C:7]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

実験手順

23.6 g of methyl 3-(3-tert-butyl-4-hydroxyphenyl)propionate, 10.1 g of glyoxylic acid monohydrate and 0.08 g of p-toluenesulfonic acid are boiled in 80 ml of 1,2-dichloroethane under a water separator for 7 h. The reaction solution is then cooled down, washed 3 times with 50 ml of water each time and freed of solvent in a rotary evaporator to leave 29.2 g of methyl 3-(7-tert-butyl-3-hydroxy-2-oxo-2,3-dihydrobenzofuran-5-yl)propionate in the form of a yellowish oil.