Hydrochloric Acid → HCID 4738324、化合物

HRID 430767ノート

反応式

HRID 430767 の反応式
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[OH-].[Na+].Cl.O>CO>[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 11435946Methyl 2-(7-methoxybenzofuran-3-yl)acetate

生成物 1

HCID 4738324HCID 4738324、化合物収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl (7-methoxy-benzofuran-3-yl)acetate (1.12 g) was dissolved in methanol (20 ml). To this solution, 2N aqueous sodium hydroxide solution (5 ml) was added and the resulting solution was stirred at room temperature for 13.5 hours. To this solution, 1N hydrochloric acid (12 ml) was added and the reaction solution was poured into water layer (200 ml), followed by extraction twice with ethyl acetate (50 ml). The organic layers were combined and washed with saturated brine, followed by drying over sodium sulfate. Sodium sulfate was removed by filtration and the solvent was removed under reduced pressure. The residue was recrystallized from hexane/chloroform to obtain the desired compound (0.95 g, yield: 91%).

後処理

  1. extractionfollowed by extraction twice with ethyl acetate (50 ml)
  2. washwashed with saturated brine
  3. dry with materialby drying over sodium sulfate
  4. customSodium sulfate was removed by filtration
  5. customthe solvent was removed under reduced pressure
  6. customThe residue was recrystallized from hexane/chloroform

出典と根拠

ORDレコード
ord-3c297ee405ad4169931342fe959e72b3
出典データセット
uspto-grants-2001_11
特許番号
US06323235B1

反応ノート

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