Trifluoroacetic acid → (Pyrole-2-carbonyl)-N-(benzyl)glycine

HRID 430942ノート

反応式

HRID 430942 の反応式
C([O:5][C:6](=[O:23])[CH2:7][N:8]([C:16]([C:18]1[NH:19][CH:20]=[CH:21][CH:22]=1)=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:16]([N:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][C:6]([OH:23])=[O:5])=[O:17]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acid2 回HCID 70020108(Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester

生成物 1

HCID 18762404(Pyrole-2-carbonyl)-N-(benzyl)glycine収率 94.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution containing 2.85 g (9.01 mmol) of (Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester in 50 mL of anhydrous dichloromethane cooled to 0° C. was added 25 mL of TFA dropwise. After 90 minutes an additional 25 mL of TFA was added and allowed to stir for 30 minutes. The mixture was evaporated in vacuo to afford 2.19 g of (Pyrole-2-carbonyl)-N-(benzyl)glycine as a tan solid. FAB MS [M+H] m/z; Calcd. 259, Found 259.

後処理

  1. customThe mixture was evaporated in vacuo

出典と根拠

ORDレコード
ord-b235befdd0b84b1db9931144d59534f0
出典データセット
uspto-grants-2003_12
特許番号
US06656910B2

反応ノート

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