N-Methylbenzylamine → 4-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one
反応式
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[O:10]1[CH2:14][CH:13]=[CH:12][C:11]1=[O:15]>C(Cl)Cl>[CH2:3]([N:2]([CH:13]1[CH2:14][O:10][C:11](=[O:15])[CH2:12]1)[CH3:1])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1参加物
4
実験手順
23.20 ml of N-methylbenzylamine are added to 15.00 g of 5H-furan-2-one in 150 ml methylene chloride. The reaction mixture is stirred for about 48 hours at ambient temperature. For working up the reaction mixture is concentrated by evaporation and chromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant. The desired product is obtained as a yellowish oil.
後処理
- concentrationis concentrated by evaporation
- customchromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant
出典と根拠
- ORDレコード
- ord-af25213858bc4f09848fe3319cfce942
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06656946B2
反応ノート
読み込み中…