N-Methylbenzylamine → 4-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one

HRID 431018

反応式

HRID 431018 の反応式
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[O:10]1[CH2:14][CH:13]=[CH:12][C:11]1=[O:15]>C(Cl)Cl>[CH2:3]([N:2]([CH:13]1[CH2:14][O:10][C:11](=[O:15])[CH2:12]1)[CH3:1])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 7669N-MethylbenzylamineHCID 103412(5H)-Furanone

生成物 1

HCID 699551354-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

23.20 ml of N-methylbenzylamine are added to 15.00 g of 5H-furan-2-one in 150 ml methylene chloride. The reaction mixture is stirred for about 48 hours at ambient temperature. For working up the reaction mixture is concentrated by evaporation and chromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant. The desired product is obtained as a yellowish oil.

後処理

  1. concentrationis concentrated by evaporation
  2. customchromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant

出典と根拠

ORDレコード
ord-af25213858bc4f09848fe3319cfce942
出典データセット
uspto-grants-2003_12
特許番号
US06656946B2

関連ノート

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