4-tert-Butyltoluene → 4-Tert-butyl-1-methyl-2-nitrobenzene
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].F[B-](F)(F)F.[O:17]=[N+:18]=[O:19]>C(#N)C.O>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:11])=[C:9]([N+:18]([O-:19])=[O:17])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]参加物
5
実験手順
To a solution of 4-tert-butyl toluene (33.7 mmol) in acetonitrile (150 mL) at 0° C. was added nitronium tetrafluoroborate (40.5 mmol). After 30 min at room temperature, the reaction was diluted with water (50 mL) and extracted with EtOAc (3×30 mL). The combined organic extracts were washed with brine and dried (MgSO4). Removal of the volatiles in vacuo left a residue; flash chromatography using 10% methylene chloride/petroleum ether as eluent provided 4-tert-butyl-2-nitrotoluene.
後処理
- extractionextracted with EtOAc (3×30 mL)
- washThe combined organic extracts were washed with brine
- dry with materialdried (MgSO4)
- customRemoval of the volatiles in vacuo
- waitleft a residue
出典と根拠
- ORDレコード
- ord-a92d0dbc87f94da19a63c986054f6f48
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06656933B2
反応ノート
読み込み中…