Hydrochloric Acid → Sodium Hydroxide

HRID 431286

反応式

HRID 431286 の反応式
[CH2:1]1[C:6]([C:7]([NH2:9])=[O:8])=[CH:5][N:4]([CH:10]2[O:14][CH:13]([CH2:15][O:16][P:17]([O:20][P:21]([O:24][CH2:25][CH:26]3[O:30][CH:29]([N:31]4[C:35]5[N:36]=[CH:37][N:38]=[C:39]([NH2:40])[C:34]=5[N:33]=[CH:32]4)[CH:28]([O:41][P:42]([O-:45])([O-:44])=[O:43])[CH:27]3[OH:46])([O-:23])=[O:22])([O-:19])=[O:18])[CH:12]([OH:47])[CH:11]2[OH:48])[CH:3]=[CH:2]1.[Na+:49].[Na+].[Na+].[Na+].ClC(Cl)(P(=O)(O)O)P(=O)(O)O.Cl>>[OH-:8].[Na+:49].[CH2:1]1[C:6]([C:7]([NH2:9])=[O:8])=[CH:5][N:4]([CH:10]2[O:14][CH:13]([CH2:15][O:16][P:17]([O:20][P:21]([O:24][CH2:25][CH:26]3[O:30][CH:29]([N:31]4[C:35]5[N:36]=[CH:37][N:38]=[C:39]([NH2:40])[C:34]=5[N:33]=[CH:32]4)[CH:28]([O:41][P:42]([O-:44])([O-:45])=[O:43])[CH:27]3[OH:46])([O-:23])=[O:22])([O-:19])=[O:18])[CH:12]([OH:47])[CH:11]2[OH:48])[CH:3]=[CH:2]1.[Na+:49].[Na+:49].[Na+:49].[Na+:49]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 25419ClodronateHCID 12598259[2-adenin-9-yl-5-[[[[5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate

生成物 2

HCID 14798Sodium HydroxideHCID 12598259[2-adenin-9-yl-5-[[[[5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate

実験手順

GB 1026366 describes the preparation of the tetrasodium salt of dichloromethylenebisphosphonic acid by refluxing dichloromethylene bisphosphonate tetraisopropyl ester with concentrated hydrochloric acid. The acidic solution was concentrated and twice azeotroped with isopropanol. Neutralisation of the acid with sodium hydroxide yielded the tetrasodium salt.

後処理

  1. concentrationThe acidic solution was concentrated
  2. customtwice azeotroped with isopropanol

出典と根拠

ORDレコード
ord-f4a992fc0f03429cbe6d51cb65e9e395
出典データセット
uspto-grants-2003_12
特許番号
US06657076B1

関連ノート

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