Hydrochloric Acid → 3-[(Bicyclo[2.2.1]hept-5-en-2-yl)(hydroxy)methyl]oxolan-2-one

HRID 431414

反応式

HRID 431414 の反応式
Br[CH:2]1[CH2:7][CH2:6][O:5][C:3]1=[O:4].[CH:8]12[CH2:14][CH:11]([CH:12]=[CH:13]1)[CH2:10][CH:9]2[CH:15]=[O:16].O1CCCC1.Cl>[Zn].CCCCCC>[OH:16][CH:15]([CH:9]1[CH2:10][CH:11]2[CH2:14][CH:8]1[CH:13]=[CH:12]2)[CH:2]1[CH2:7][CH2:6][O:5][C:3]1=[O:4]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 95117Bicyclo(2.2.1)hept-5-ene-2-carboxaldehydeHCID 954632(3H)-Furanone, 3-bromodihydro-

生成物 1

HCID 183456893-[(Bicyclo[2.2.1]hept-5-en-2-yl)(hydroxy)methyl]oxolan-2-one収率 71.2%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 8058Hexane溶媒

実験手順

Addition reaction was carried out by mixing 98 g of zinc powder, 247 g of α-bromo-γ-butyrolactone, 122 g of 5-norbornene-2-carbaldehyde, and 2 kg of dry tetrahydrofuran and heating the mixture under reflux for 10 hours in a nitrogen atmosphere. The reaction mixture was cooled, to which dilute hydrochloric acid was added for neutralization and hexane was added for extraction. The organic layer was washed with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuum. Purification by silica gel column chromatography yielded 148 g (yield 71%) of α-[hydroxy(5-norbornen-2-yl)methyl]-γ-butyrolactone.

後処理

  1. additionAddition reaction
  2. temperatureheating the mixture
  3. temperatureunder reflux for 10 hours in a nitrogen atmosphere
  4. additionwas added for extraction
  5. washThe organic layer was washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuum
  9. customPurification by silica gel column chromatography

出典と根拠

ORDレコード
ord-88b6649bad3446cd9463ae695dd1dc8e
出典データセット
uspto-grants-2003_12
特許番号
US06660448B2

関連ノート

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